酸盐和相关的能量代谢物调节了对高基因眼风险的抵抗力
bioRxiv : the preprint server for biology
|February 3, 2025
概括
可以使用多基因风险评分 (PRS) 识别眼风险,但一些高风险个体仍然具有弹性. 代谢物,特别是酸盐,表现出保护作用,这表明了预防青光眼的新治疗点.
科学领域:
- 眼科医生 眼科 眼科
- 代谢学 代谢学 代谢学
- 遗传学 遗传学 是一个
背景情况:
- 玻璃眼多原风险评分 (PRS) 识别疾病易感性.
- 然而,并非所有患有高PRS的人都会患上青光眼,这表明了弹性因素.
- 了解这些弹性机制对于有效的绿眼病管理至关重要.
研究的目的:
- 为了调查血代谢物是否能改善青光眼的预测.
- 为了确定高遗传眼风险的个体中适应力的代谢特征.
- 为了验证特定代谢物的作用在青光眼的小鼠模型中.
主要方法:
- 来自英国生物库的4,658例青光眼病例和113,040例对照的横截面研究.
- 后勤回归模型包括168种基于NMR的代谢物和PRS.
- 实验验证使用一种小鼠模型 (Mus musculus) 与饮食中的pyruvate.
主要成果:
- 仅仅代谢物预测的玻璃眼 (AUC=0.579) 较弱,但略有改善PRS模型.
- 高PRS个体的弹性特征包括高的糖解代谢物:乳酸盐,酸盐和酸盐.
- 饮食中的酸盐在小鼠绿眼瘤模型中降低了眼内压力和视神经损伤.
结论:
- 血代谢物,特别是与糖解和酸盐代谢相关的代谢物,与对玻璃眼的抵抗力有关.
- 酸显示出对玻璃眼病原体的保护作用,这在人类数据和小鼠模型中得到证实.
- 这些发现表明,潜在的治疗策略针对的新陈代谢途径,以预防和治疗青光眼.
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