在城市群岛的时间尺度上的人口历史
Emma K Howell1, Lauren E Nolfo-Clements2, Bret A Payseur1
1Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI.
bioRxiv : the preprint server for biology
|February 3, 2025
概括
波士顿港白足小鼠的基因组分析揭示了人口规模的变化和最近的迁移. 这项研究通过检查多种遗传变异模式,增强了对人口史的理解.
科学领域:
- 人口遗传学 人口遗传学
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
背景情况:
- 遗传变异模式反映了人口的进化历史,包括分裂,迁移和尺寸变化.
- 目前用于重建人口历史的方法往往缺乏时间分辨率以捕捉随时间的动态变化.
研究的目的:
- 在城市化波士顿港群岛中推断白足小鼠 (Peromyscus leucopus) 的人口统计历史.
- 证明整合多种基因组变异总结的实用性,以延长人口统计推断的时间分辨率.
主要方法:
- 三种特有Peromyscus leucopus种群的全基因组测序.
- 分析使用既建立的 (联合站点频谱 - jSFS) 和新的变化摘要.
- 从不同的基因组数据模式推断出人口统计模型的比较分析.
主要成果:
- 基于jSFS的人口模型与波士顿港的地质历史一致.
- 链接不平衡模式表明最近的种群规模减少没有被jSFS模型所捕捉.
- 罕见的变种聚类表明最近的迁移,在jSFS模型中缺少但由模拟支持的模式.
结论:
- 城市群岛的Peromyscus leucopus种群是由古老的地质事件和最近的人类影响所塑造的.
- 检查多个基因组变异方面,提供了更为时间解决的人口历史的观点.
- 整合多样化的遗传数据可以改善动态进化过程的特征.
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