饮食中的蛋白质来源通过细菌对胆汁酸的调节来调节大肠炎的发病
Simon M Gray1, Michael C Wood2, Samantha C Mulkeen2
1Center for Gastrointestinal Biology and Disease, Department of Medicine, University of North Carolina, Chapel Hill, NC.
从红肉蛋白转换为植物性蛋白质可以减少炎症性肠道疾病 (IBD) 中的肠道炎症. 牛肉蛋白在小鼠中恶化了结肠炎,而豆蛋白具有较轻的效果,这表明蛋白质来源会影响肠道健康.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 对于炎症性肠病 (IBD) 的饮食建议是有限的.
- 红肉消费与IBD发病率和复发率的增加有关.
- 植物性饮食可能会减轻肠道炎症,但潜在的机制尚不清楚.
研究的目的:
- 研究植物和动物衍生蛋白对肠道炎症的差异性影响.
- 在小鼠模型中阐明牛肉蛋白促进结肠炎的机制.
主要方法:
- 小鼠结肠炎模型被食牛肉蛋白 (BP) 或豆蛋白 (PP).
- 微生物群操纵 (枯竭,移植) 用于评估微生物介导.
- 分析了便胆酸 (BA) 概况和粘液层完整性.
- 评估了草补充剂的影响.
主要成果:
- 给BP养的小鼠表现出严重的结肠炎,而给PP养的小鼠表现出轻微的炎症.
- 高血压诱导的大肠炎是微生物介导的.
- 高血压养改变了肠道微生物群的组成,降低了粘液层的质量.
- 在给BP养的小鼠中观察到便胆酸的升高,而taurocholic酸加剧了结肠炎.
- 普西保护了BP介导的炎症和正常化的BA形状.
结论:
- 红肉中的蛋白质成分可能会促进结肠炎.
- 微生物和胆汁酸的改变是BP诱导的肠道炎症的关键机制.
- 通过调节肠道环境,像树这样的饮食干预措施可能为IBD提供治疗潜力.
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