相关实验视频

Updated: May 29, 2025

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

2.9K

多细胞适应机械化学的Piezo1-Erk1/2-Yap1细胞增殖轴,以微调中心数

Vani Narayanan, Venkatramanan G Rao, Angelo Arrigo

    bioRxiv : the preprint server for biology
    |February 3, 2025
    PubMed
    概括

    多细胞通过涉及Piezo1,Erk1/2和Yap1.2的机械化学途径放大中心细胞. 这一过程激活了转录因子Foxj1,这对运动乳毛发育和流体流动至关重要.

    更多相关视频

    Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes09:39

    Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

    Published on: December 20, 2014

    15.1K
    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro09:50

    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

    Published on: August 27, 2015

    8.2K

    相关概念视频

    Centrioles and Centrosomes01:13

    Centrioles and Centrosomes

    Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
    Near the end of the prophase, also called late prophase or...
    2.5K
    Cell Motility through Blebbing01:16

    Cell Motility through Blebbing

    Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
    Blebbing Through the Matrix
    In multicellular...
    1.9K
    Cell-matrix's Response to Mechanical Forces01:13

    Cell-matrix's Response to Mechanical Forces

    In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
    Anchoring junctions mechanically attach a cell to the...
    2.5K
    Cells Coordinate Growth and Proliferation02:36

    Cells Coordinate Growth and Proliferation

    Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
    4.5K
    Tension Response at Adherens Junctions01:26

    Tension Response at Adherens Junctions

    The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
    α-Catenin as a Mechanosensory Protein
    The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
    2.6K
    Centrosome Duplication02:25

    Centrosome Duplication

    The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
    To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
    3.9K