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Mef2c通过调节对以林排斥的敏感性来控制产后状轴向向

Sriram Sudarsanam^1,2, Luis Guzman-Clavel^1,2, Nyle Dar¹

¹The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

bioRxiv : the preprint server for biology

|February 3, 2025

概括

转录因子Mef2c调节大脑皮层中神经元发育和轴突向. 它控制子类型的规范,并引导callosal投射神经元到它们的正确目标.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
分子生物学分子生物学

背景情况:

皮层连接依赖于精确的神经元亚型发展和轴突投射.
控制皮质内轴突向的机制,特别是对于状突出,仍然不完全理解.

研究的目的:

研究转录因子肌细胞增强因子2-c (Mef2c) 在皮层发育中的作用.
阐明Mef2c在体感皮层 (S1) 神经元的特异化中的作用,以及对2/3层状投射神经元 (L2/3 CPNs) 的向.

主要方法:

利用基因操纵研究Mef2c在发育皮层神经元中的功能.
研究了Mef2c和EphA-EphrinA信号通路之间的相互作用.
在Mef2c突变模型中分析了L2/3 CPNs的轴突向.

主要成果:

在胚胎发生过程中,Mef2c指导S1层4和5金字塔神经元的发育.
在产后,Mef2c表达转移到L2/3 CPNs,在那里它调解了对同位素相对边皮层区域的向.
Mef2c降低了EphA6的表达,使S1-L2/3 CPN轴突对以弗林A5介导的排斥变得不敏感.

结论:

在皮层发育中,Mef2c表现出双重作用:调节神经元亚型的规范和指导产后状轴突的向.
这项研究揭示了Mef2c在通过调制Ephrin信号传递来引导长距离轴突突投射的新机制.

关键词:

埃弗林斯是什么意思皮质内连接性皮质内连接性这就是Mef2cc.轴突指导指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导导轴突指导导轴突指导轴指导轴指导轴指导轴指导身体的质体 (callosum) 是一个体.新皮质新皮质的新皮质

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