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Updated: May 29, 2025

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烟草烟雾的致癌物加剧了APOBEC的突变和致癌

Cameron Durfee1, Erik N Bergstrom2,3,4, Marcos Díaz-Gay2,3,4,5

  • 1Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229.

bioRxiv : the preprint server for biology
|February 3, 2025
PubMed
概括

像NQO这样的烟草致癌物放大致癌APOBEC3B (A3B) 突变,协同增加突变和头瘤. 这种相互作用,标志着称为迪迪玛的配对突变,在吸烟者中升高.

关键词:
在APOBEC的突变发生过程中.庞大的DNA添加物.癌症的发展和进展.核酸切除修复的修复烟草是致癌物质的

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