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Updated: May 29, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

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纤维细胞密度是药物诱导心律失常的危险因素

Kayo Hirose, Shinjiro Umezu, Daisuke Sato

    bioRxiv : the preprint server for biology
    |February 3, 2025
    PubMed
    概括

    纤维细胞影响药物诱导的心律失常,纤维化密度对早产腹腔复合体 (PVCs) 的双相影响. 纤维化密度的增加增强了心律失常的自我持续性,突出了纤维化和动作潜能持续时间异质性之间的相互作用.

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    Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
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    Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
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