相关实验视频

Updated: May 29, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

N,N-二甲基胺阻断炎症诱导的早产,并修复母亲的全身免疫反应

Sandra E Reznik^1,2, Alexander Kashou³, Daylan Ward³

¹Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY 11439.

bioRxiv : the preprint server for biology

|February 3, 2025

概括

N,N-二甲基胺 (DMA) 通过减少对脂聚糖 (LPS) 的炎症反应,防止小鼠早产. DMA允许怀孕继续到期,证明其有潜力减轻妊娠不良后果.

科学领域:

生殖生物学生殖生物学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

早产是新生儿死亡的主要原因.
细菌内毒素,如脂聚糖 (LPS),触发炎症反应和早产.
N,N-二甲基胺 (DMA) 是一种常见的辅助剂,有可能调节这些反应.

研究的目的:

调查DMA是否可以预防小鼠LPS诱导的早产.
为了确定DMA是否减轻母亲的全身炎症和子宫重塑.
评估DMA对维持怀孕和及时分娩的影响.

主要方法:

小鼠接受LPS诱导早产,与或没有DMA治疗.
测量了母亲的血细胞因子 (促炎和抗炎) 和孕激素水平.
监测了宫重塑和分娩时间.

主要成果:

DMA治疗防止了LPS诱导的早产,允许在期限内分娩.
DMA并没有阻止母体细胞因子的初始增加,但后来减少了特定的炎症标志物.
DMA减轻了孕激素的短暂下降,并防止了过早的宫重塑.

结论:

通过调节母亲的炎症反应和荷尔蒙变化,DMA有效地预防炎症驱动的早产.
DMA拯救了怀孕,使得在不损害胎儿生存能力的情况下实现了预期分娩.
这些发现表明,DMA是减轻早产和改善妊娠结果的潜在治疗剂.

关键词:

宫的子宫可以细胞因子细胞因子产妇分娩产妇分娩怀孕怀孕怀孕怀孕怀孕

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

相关概念视频

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...