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Updated: May 29, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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适应性可塑性瘤细胞调节结肠直肠癌中MAPK向治疗反应

Oscar E Villarreal, Yixin Xu, Ha Tran

    bioRxiv : the preprint server for biology
    |February 3, 2025
    PubMed
    概括

    在结直肠癌中,MAPK通路抑制剂 (MAPKi) 的耐用性有限. 新的研究确定了由ASCL2驱动的适应性可塑性瘤 (APT) 细胞,这些细胞抵抗MAPKi,这表明向可塑性可以改善治疗结果.

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