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Updated: May 29, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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PI3K调节TAZ/YAP和mTORC1轴,可以协同准这些轴

Keith C Garcia, Ali A Khan, Krishnendu Ghosh

    bioRxiv : the preprint server for biology
    |February 3, 2025
    PubMed
    概括

    针对PI3K-TAZ/YAP通路进行组合疗法,包括TEAD和mTORC1抑制剂,显示出治疗PI3K激活瘤的前景. 这种方法在临床前模型中协同减少瘤生长和扩散.

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