一个胆固醇脊柱通路用于适应性控制呼吸
Minshan Lin1, Giulia Benedetta Calabrese2, Anthony V Incognito3
1Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
研究人员发现了一条新的脊柱通路,通过激活动神经元 (PMN) 来放大呼吸. 这条涉及V0C胆性内神经元的途径对于响应超症至关重要,并且可能有助于脊髓损伤后的恢复.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 发动机控制器的控制器
背景情况:
- 运动神经元 (MN) 输出放大对于强烈的运动动作和呼吸调节至关重要.
- 大脑干电路控制呼吸节奏,但增加呼吸 MN 输出的途径尚不清楚.
研究的目的:
- 为了识别和描述直接增加脑神经元 (PMN) 输出的脊柱路径.
- 了解V0C胆能内神经元在呼吸控制和超反应中的作用.
主要方法:
- 将第一阶输入映射到动神经元 (PMN).
- 对V0C胆性内部神经元的遗传鉴定.
- 电生理学记录和药理学操纵 (M2肌糖体受体对抗剂).
- 评估对超的呼吸反应的挑战和胆固醇内神经元的沉默.
主要成果:
- 在PMN中占主导地位的脊柱输入源自V0C胆性内部神经元.
- 这些内部神经元从脑干呼吸中心接收相位刺激.
- 胆固醇内部神经元的激活通过M2肌受体增加了的输出.
- 沉默这些内部神经元会损害呼吸对高头症的反应.
结论:
- 一个涉及V0C胆能内部神经元的新型脊柱通路放大了呼吸.
- 这条通路对于呼吸系统对高头症的反应至关重要.
- 这一途径代表了在脊髓损伤后改善呼吸的潜在治疗目标.
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