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Updated: May 29, 2025

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
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2型糖尿病中人类小岛细胞类型特异性变化的单细胞解码揭示了融合的遗传和状态驱动的细胞基因表达缺陷

Khushdeep Bandesh1, Efthymios Motakis1, Siddhi Nargund1

  • 1The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032 USA.

bioRxiv : the preprint server for biology
|February 3, 2025
PubMed
概括

这项研究揭示了2型糖尿病 (T2D) 中功能β细胞质量的显著损失,确定了参与人类小岛功能障碍的关键基因和途径. 这些发现为T2D提供了新的治疗点.

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