病毒病不能独立预测艾滋病毒感染者的心血管疾病:一个响应队列研究
Olof Elvstam1,2, Lene Ryom3,4,5, Bastian Neesgaard3
1Department of Translational Medicine, Lund University, Malmö, Sweden.
Open forum infectious diseases
|February 3, 2025
概括
当考虑已确定的风险因素时,艾滋病毒病毒症不是艾滋病毒感染者心血管疾病 (CVD) 的风险因素. 这项研究没有发现病毒病与心血管疾病事件之间的显著关联,也没有改善心血管疾病预测模型.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 人们一直怀疑艾滋病病毒症是心血管疾病 (CVD) 风险因素.
- 之前的研究往往缺乏关键混因素的数据.
- 这项研究解决了对病毒病在心血管疾病中的作用进行强有力的分析的需求.
研究的目的:
- 调查艾滋病毒病毒和心血管疾病之间的关联.
- 为了确定病毒病是否改善心血管疾病风险预测,在考虑到已确定的风险因素之后.
主要方法:
- 在一个大型国际队列 (RESPOND) 中分析了6项HIV病毒性病的测量.
- 根据已确定的心血管疾病风险因素进行调整,使用D:A:D心血管疾病分数组件.
- 使用内部交叉验证,比较有和没有病毒病的CVD预测模型.
主要成果:
- 在调整了混因子后,没有发现任何衡量HIV病毒性和心血管疾病事件之间的统计学上显著的关联.
- 测量包括当前的病毒载量,ART前的病毒载量和累积的病毒血量.
- 病毒病变量没有提高心血管疾病风险模型的预测能力.
结论:
- 当考虑到已确定的风险因素时,艾滋病毒病毒症与艾滋病毒感染者的心血管疾病没有独立相关.
- 病毒病似乎不是这一群体中心血管疾病的重要预测因素.
- 进一步的研究可能将重点放在其他影响心血管疾病风险的HIV特异性因素上.
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