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综合分析与二硫化相关的基因和心力衰竭中的免疫微环境

Linna Zhao¹, Juanjuan Zhang^2,3, Qiuhang Song³

¹Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.

Frontiers in cell and developmental biology

|February 3, 2025

概括

与失硫致死相关的基因 (DRG) 显著影响心力衰竭 (HF) 免疫微环境. 生物信息学分析揭示了四个关键的DRG,可以预测HF并影响免疫细胞透,特别是单细胞.

科学领域:

心血管研究研究心血管研究
免疫学免疫学免疫学
生物信息学是一种生物信息学.

背景情况:

心力衰竭 (HF) 是一种广泛的心血管疾病,具有复杂的发病因子和有限的治疗方法.
脱硫致死,一种新的细胞死亡途径,与各种疾病有关.
硫化灭菌在高频免疫微环境中的作用尚不清楚.

研究的目的:

使用生物信息学研究与二硫化相关基因 (DRG) 对高频免疫微环境的影响.
在DRG表达的基础上识别HF的潜在生物标志物.

主要方法:

对大量和单细胞RNA测序数据的分析,以检查高频的四个关键DRG.
基于DRG表达的HF预测模型的开发和验证.
探索DRG对免疫细胞透,免疫反应基因和HLA基因的影响.

主要成果:

在HF样本中,所有四个检查的DRG都被发现是失调的.
使用这四个DRG的预测模型准确地将HF患者与健康个体区分开来.
DRG显示与单细胞丰富度和DRG集群之间的独特免疫特征有很强的相关性.

结论:

与脱硫致死相关的基因在塑造HF免疫微环境方面发挥着至关重要的作用.
这些发现突出了DRG作为潜在的治疗点和HF的诊断标记.

关键词:

硫化物脱硫症 (disulfidptosis) 是一种脱硫症.心脏衰竭是因为心脏衰竭.免疫微观环境免疫微环境分子集群的分子集群.亚型子类型亚型子类型

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