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针对与代谢功能障碍相关的脂肪性肝病 (MASLD):现有和未来的药物选择
Emmanouil Koullias1, Maria Papavdi1, John Koskinas1
1Second Department of Internal Medicine, Hippocration General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 缺乏向药物. 本综述探讨了现有和新兴的药物治疗方法,包括针对肥胖和2型糖尿病的药物治疗方法,以改善患者的治疗结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 在针对MASLD的肝脏特异性药物开发中存在重大差距.
- MASLD经常与肥胖和2型糖尿病 (T2DM) 一起发生.
研究的目的:
- 对MASLD治疗的现有和新型药物策略进行审查.
- 探索重定向药物和现有的代谢性疾病药物对MASLD的潜力.
- 提供治疗选择的概述,以改善MASLD患者的治疗结果.
主要方法:
- 对针对MASLD病原体的管道药物的文献综述.
- 对肥胖和T2DM (例如GLP-1RAs,SGLT2-is) 已批准的药物的分析,以寻找潜在的MASLD益处.
- 综合有关已建立和新兴药物干预措施的信息.
主要成果:
- 研究正在调查针对MASLD涉及的多个受体的药物.
- 已批准用于肥胖和T2DM的药物,如葡萄糖样-1受体激动剂 (GLP-1RAs) 和-葡萄糖共同输送物-2抑制剂 (SGLT2-is),对MASLD有希望.
- 这些类别中的现有和即将推出的药物都提供了潜在的治疗途径.
结论:
- 对于MASLD来说,制药领域正在不断发展,重点是新型药物和重新设计的疗法.
- 利用对T2DM和肥胖等相关代谢疾病的治疗方法是关键策略.
- 进一步的研究和临床试验对于优化MASLD的药物干预至关重要.
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