开发和验证基于系统性炎症响应指数的诺姆图,用于预测急性无并发型B型大动脉内腔血瘤患者的短期不良事件
Yasong Wang1,2, Xuan Wu2, Yue Wang2
1Graduate School of Dalian Medical University, Dalian Medical University, Dalian, 116044, People's Republic of China.
Journal of inflammation research
|February 3, 2025
概括
使用系统性炎症响应指数 (SIRI) 的新名录有效预测急性无并发型B型内腔血瘤 (IMH) 患者的短期大动脉相关不良事件 (ARAE). 该工具有助于评估患者的风险,以便更好地管理.
科学领域:
- 心血管医学 心血管医学
- 血管外科 血管外科
- 预测分析是一种预测分析.
背景情况:
- 急性无并发性B型室内血瘤 (IMH) 存在大动脉相关不良事件 (ARAE) 的风险.
- 准确预测短期ARAEs对于及时干预和改善患者结果至关重要.
- 系统性炎症反应指数 (SIRI) 已成为各种炎症状况中的潜在生物标志物.
研究的目的:
- 开发和验证一种预测B型IMH急性无并发症患者短期ARAE的诺米克图.
- 评估SIRI与ARAE临床因素的预测价值.
- 建立一种临床上适用的工具,用于IMH患者的风险分层.
主要方法:
- 对332名急性无并发性B型IMH患者的回顾性分析.
- 使用中性粒细胞,单细胞和淋巴细胞计数计算SIRI.
- 使用后勤回归,LASSO,AUC,校准曲线,DCA和NRI开发和验证两个名图 (临床和临床-SIRI).
主要成果:
- 临床-SIRI名谱显示出与临床名谱 (AUC=0.742) 相比,更高的预测准确度 (AUC=0.788).
- 鉴定出SIRI是ARAE的独立预测因子,显著提高预测准确度 (NRI=0.521).
- 贫血,糖尿病,最大的大动脉直径和状的投射也是重要的预测因素.
结论:
- 基于SIRI的诺基图作为一个有价值的预后工具,用于预测B型IMH急性无并发症的短期ARAE.
- 将SIRI纳入该患者队列中增强了ARAE临床变量的预测能力.
- 开发的诺姆图为改善临床决策和患者管理提供了潜力.
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