在接受血液透析的患者中,与感染相关的 CD73-腺素信号的改变
Fangfang Xiang1,2,3,4, Zhen Zhang1, Yuxin Nie1
1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Journal of inflammation research
|February 3, 2025
概括
较低的CD73+ T细胞计数增加了血液透析患者的感染风险. 这表明受损的CD73-adenosine信号传递有助于慢性病中免疫功能障碍.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
背景情况:
- 感染是血液透析 (HD) 患者死亡和住院的主要原因.
- 酶CD73 (5'-核酶) 通过腺素调节炎症和抗炎症信号.
- 减少CD73-adenosine信号传递与严重感染有关.
研究的目的:
- 为了研究CD73+ T细胞比率与HD患者感染风险之间的关联.
- 探索CD73-adenosine信号传递在慢性病 (CKD) 中免疫功能障碍中的作用.
主要方法:
- 对393名HD患者进行了前性队列研究,并对其进行了3年的随访.
- 对CD73+T细胞比率,感染事件和死亡率的分析.
- 使用大鼠模型 (5/6腎切除和頭結束/穿刺) 來研究CKD和毒症對CD73-adenosine信號的影響.
主要成果:
- 较低的CD73+T细胞水平独立地与感染风险增加有关 (1年HR: 3.173,3年HR: 1.429).
- 降低CD73+ T细胞与复发性和致命性严重感染相关.
- 慢性瘤和败血症模型显示CD73表达减少,腺水平和信号受损.
结论:
- 降低CD73+T细胞水平是HD患者感染的重要危险因素.
- 改变的CD73-adenosine信号传递是CKD中观察到的免疫功能障碍的关键贡献者.
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