美国成年人中氧化平衡得分与外周动脉疾病之间的关联:一个横截面研究
Min Zhou1,2, Peng-Fei He2,3, Keren Zhang1
1Department of Peripheral Vascular Surgery, Dongzhimen Hospital, Beijing, China.
Frontiers in nutrition
|February 3, 2025
概括
较高的氧化平衡得分 (OBS) 与降低外周动脉疾病 (PAD) 风险相关. 健康的生活方式和饮食,以及管理葡萄糖和肌素水平,可能有助于降低PAD发病率.
科学领域:
- 心血管健康 心血管健康
- 氧化压力研究研究 氧化压力研究
- 营养流行病学 营养流行病学
背景情况:
- 周围动脉疾病 (PAD) 是一种严重的血管疾病.
- 氧化压力在心血管疾病中起作用.
- 氧化平衡评分 (OBS) 衡量了抗氧化和抗氧化平衡.
研究的目的:
- 调查氧化平衡得分 (OBS) 与外围动脉疾病 (PAD) 之间的关联.
- 探索生活方式和饮食因素之间的关系,这些因素有助于OBS和PAD风险.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (1999-2004).
- 后勤回归和受限立方线 (RCS) 分析,以评估OBS-PAD关联和剂量反应关系.
- 调解分析以探索葡萄脂代谢和功能的作用.
主要成果:
- 较高的总OBS和生活方式OBS与PAD可能性有负相关性.
- 在总OBS和PAD之间观察到线性反向关系.
- 在OBS组件和脚-手臂指数 (ABI) 水平之间发现了正线性相关性.
- 禁食血葡萄糖 (FPG) 和肌素 (CREA) 部分调解了OBS-PAD相关性.
结论:
- 增加OBS,反映出更好的抗氧化剂平衡,与较低的PAD风险有关.
- 促进富含抗氧化剂的饮食和健康的生活方式可能会降低PAD风险.
- 针对FPG和CREA水平可能有利于管理与低OBS相关的PAD风险.
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