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Updated: May 29, 2025

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一个基于矩阵金属蛋白酶敏感的多功能平台,用于关节炎的新型诊断和治疗策略

Mingyang Li1, Tao Deng1, Quan Chen1

  • 1Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Bioactive materials
|February 3, 2025
PubMed
概括

矩阵金属蛋白酶 (MMPs) 是关节炎的关键. 对MMP敏感 (MSP) 提供了新的方法来诊断诸如骨关节炎和类风湿性关节炎等疾病,并有效地提供药物.

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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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