斑马鱼发育模型的进展,用于预测人类毒理学
Mackenzie L Morshead1, Robyn L Tanguay1
1Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University 28645 East Highway 34, Corvallis, OR 97331, USA.
Current opinion in toxicology
|February 3, 2025
概括
斑马鱼在生命早期阶段为哺乳动物测试提供了强大的替代方案,以快速评估化学危害. 它们在高通量查中的使用为预测毒理学和QSAR建模产生了有价值的数据.
科学领域:
- * 毒理学和生态毒理学
- * 脊椎动物模型系统
- * 预测性毒理学 预测性毒理学
背景情况:
- *用于化学危害评估的哺乳动物测试是耗时且道德上具有挑战性的.
- * 需要快速,可靠的方法来评估化学毒性.
- * 斑马鱼在生命早期阶段为毒性测试提供了一个有前途的脊椎动物模型.
研究的目的:
- * 审查在预测性人类毒理学中使用早期生命阶段斑马鱼的进展和挑战.
- *强调斑马鱼适合进行高通量发育毒性测试.
- *讨论斑马鱼数据在QSAR和剂量建模中的价值.
主要方法:
- * 关于斑马鱼发育毒性测试的当前文献的综述.
- * 对各种研究类型 (微生物组,跨代人等) 的斑马鱼模型优势的分析. ) 的情况.
- *对定量结构-活性关系 (QSAR) 和剂量建模的数据实用性的评估.
主要成果:
- *斑马鱼很容易接受对发育毒性的高通量选.
- *它们为微生物组和跨代研究等复杂研究提供了优势.
- *斑马鱼研究的数据对于预测性危险评估和QSAR建模有价值.
结论:
- * 斑马鱼在生命早期阶段是减少化学危害评估中的哺乳动物测试的领先模型.
- *它们的实用性扩展到复杂的毒理学调查和数据驱动的预测建模.
- * 持续的进步对于优化斑马鱼在人类毒理学中的使用至关重要.
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