对2型糖尿病和骨质疏松症之间的相互作用的分子见解:对内分泌健康的影响
Liyun Jiang1, Xia Song1, Li Yan2
1Medical Laboratory Center, The First Hospital of Lanzhou University, Lanzhou, China.
Frontiers in endocrinology
|February 3, 2025
概括
二型糖尿病 (T2DM) 和骨质疏松症有联系. T2DM通过代谢变化和炎症损害骨健康,维生素D受体基因变异为糖尿病患者的骨健康管理提供了新的见解.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 骨生物学 骨生物学 骨生物学
背景情况:
- 2型糖尿病 (T2DM) 和骨质疏松症是常见的慢性疾病,具有重大的全球健康影响.
- 了解T2DM和骨质疏松症之间的复杂生物联系对于改善患者护理和治疗方法至关重要.
研究的目的:
- 审查目前关于连接T2DM和骨质疏松症的机制的研究.
- 阐明骨代谢,自,铁和维生素D受体 (VDR) 基因多态性在T2DM相关的骨质疏松症中的作用.
主要方法:
- 系统审查最近的科学文献.
- 对研究研究T2DM与骨健康相关的细胞和分子途径的分析.
主要成果:
- T2DM与减少骨形成和增加骨再吸收有关,这是由荷尔蒙变化,炎症和异常细胞信号驱动的.
- 周围脏脂肪厚度的增加通过局部炎症和改变的阿迪波金 (adipokine) 概况加剧了骨质疏松症.
- 维生素D受体 (VDR) 基因多态性为T2DM与骨质疏松症的关系提供了新的分子见解.
结论:
- 针对特定机制的有针对性的干预措施可以改善T2DM患者的骨健康.
- 需要进一步的研究来充分了解这些关联,并制定T2DM相关骨质疏松症的有效预防和治疗策略.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Carbohydrate Metabolism
10.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.7K
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Psychoneuroimmunology: Diabetes and Cancer
22
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
22
The Endocrine System
214
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
214
Pathophysiology of Diabetes
852
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
852


