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Updated: May 29, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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Cdk6的功能通过其独特的C端进行了批判性调节

Alessia Schirripa1, Helge Schöppe2, Sofie Nebenfuehr1

  • 1Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

iScience
|February 3, 2025
PubMed
概括

CDK6 (环素依赖激酶6) 的C端对其促进细胞增殖的功能至关重要. 切断这一部分会损害核转移和与关键合作伙伴的结合,阻碍白血病的进展.

关键词:
生物化学 生物化学癌症 癌症 癌症 癌症分子结构分子结构结构生物学是结构生物学.

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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