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Updated: May 29, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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分子模拟揭示了激素结合β-上腺素受体和G蛋白之间的复杂合

Yanxiao Han1, John R D Dawson1,2, Kevin R DeMarco1

  • 1Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.

iScience
|February 3, 2025
PubMed
概括

计算机模拟揭示了上腺素 (NE) 如何与β1和β2上腺素受体 (βAR) 相互作用,影响G蛋白信号传递. 这些见解可以指导向βAR药物的开发.

关键词:
计算生物信息学是指计算机生物信息学.蛋白质结构方面 蛋白质结构方面

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