纳米乳液:超声波辅助提取和表征
Mohamed Ibrahim Younis1,2, Ren Xiaofeng2, Mohammad Ali Hesarinejad3
1Food Science Department, Faculty of Agriculture Cairo University Giza Egypt.
Food science & nutrition
|February 3, 2025
概括
超声波辅助提取显著提高了Sophora japonica的生物活性化合物回收,产生更强大的抗氧化剂提取物. 这些提取物形成稳定的纳米乳液,显示出食品和制药应用的前景.
科学领域:
- 植物化学和天然产品提取
- 纳米技术和配方科学 纳米技术和配方科学
背景情况:
- 日本 (Fabaceae家族) 具有公认的药用特性,在传统亚洲医学中使用.
- 有效提取生物活性化合物并将其配制成稳定的输送系统对于治疗应用至关重要.
研究的目的:
- 评估超声波辅助提取 (UAE) 来提高Sophora japonica生物活性化合物的回收.
- 从阿联提取物中制备稳定的纳米乳液,并评估其抗氧化活性和稳定性.
主要方法:
- 使用乙醇和超声波辅助提取 (UAE) 的比较提取.
- 通过DPPH试验量化总含量 (TPC) 和评估抗氧化活性.
- 从提取物中制备纳米乳液,然后进行颗粒大小,泽塔潜力和氧化稳定性分析.
主要成果:
- 阿联的产量较高的TPC (65.57毫克GAE/毫升) 和DPPH清理活动 (67%) 相比化 (51.18毫克GAE/毫升,59%).
- 来自阿联提取物的纳米乳液表现出有利的特性 (252.92 nm粒子大小,-36.68 mV泽塔电位),表明其稳定性良好.
- 与乙醇纳米乳液相比,水基纳米乳液在5天的时间内表现出优异的氧化稳定性.
结论:
- 超声波辅助提取是一种有效的方法,可以最大限度地提高Sophora japonica的生物活性化合物产量和抗氧化剂潜力.
- 来自阿联的提取物可以配制成具有增强性能的稳定纳米乳液.
- 这些稳定的纳米乳液具有在食品和制药行业应用的巨大潜力.
相关概念视频
01:16Bioavailability Enhancement: Drug Solubility Enhancement
504
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
504
01:17In Vitro Drug Dissolution: Alternative Methods
389
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
389