优化含有橄树叶提取物和微囊香精油的粘膜口膜,具有潜在的抗菌活性
Kubra Goktas1, Dilek Yalcin1, Cansu Erdem1
1Department of Bioengineering Ege University Izmir Turkey.
Food science & nutrition
|February 3, 2025
概括
研究人员开发了一种新型的粘膜口膜,其中包含橄叶提取物 (OLE) 和微封装的西红精油 (TEO). 这些片显示出有前途的抗氧化和抗病毒活性,具有良好的粘膜粘合性和用于药物输送的物理性质.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 开发有效的口服药物输送系统需要具有粘粘性和增强生物活性的材料.
- 橄叶提取物 (OLE) 和提精油 (TEO) 具有已知的抗氧化,抗病毒和抗菌特性.
研究的目的:
- 开发和优化含有优化度的OLE和微封装TEO的粘膜口腔膜.
- 评估新型口腔膜的物理,机械,粘膜和生物活性特性.
主要方法:
- 使用电喷技术对TEO进行微封装,并采用Box-Behnken设计进行优化.
- 使用多变量盒式设计优化膜成型聚合物 (Carbopol 934,HPMC,PEG).
- 薄膜的表征包括物理,机械,粘膜粘附,抗氧化剂,细胞毒性,抗病毒和抗菌分析.
主要成果:
- 优化的电喷涂和薄膜配方产生了具有理想拉伸强度,灵活性,膨胀能力和粘膜粘合力的薄膜.
- 片显示出显著的抗氧化能力和抗病毒活性,对抗1型脊髓灰质炎病毒 (32.39%) 和小鼠诺罗病毒 (54.29%).
- 片对纤维细胞无毒,并显示金黄色葡萄球菌的逻辑减少,尽管直接抗菌作用有限.
结论:
- 开发的结合OLE和微封装TEO的粘粘性口腔膜具有良好的物理和粘粘性.
- 薄膜具有显著的抗氧化和抗病毒潜力,表明在口服药物输送中具有实用性.
- 需要进一步的研究,以提高抗微生物药物的有效性,以更广泛的应用.
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