休时间的体育活动模式,阿尔茨海默病的标志物和认知之间的关系
Sarah-Naomi James1,2, Carole H Sudre1,2,3,4, Josephine Barnes2
1MRC Unit for Lifelong Health and Ageing at UCL, Department of Population Science and Experimental Medicine, University College London, London WC1E 7HB, UK.
Brain communications
|February 3, 2025
概括
在整个成年期保持体力活动,尤其是在早期,与70岁时更好的大脑健康和认知功能有关. 终身活动可以缓冲阿尔茨海默病标志物,特别是女性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病 (AD) 构成了重大的公共卫生挑战,神经退行和认知衰退在临床诊断前几年就显而易见.
- 休时间体育活动 (LTPA) 是一种可修改的生活方式因素,具有潜在的神经保护性益处,但其对AD生物标志物和认知的长期影响需要进一步阐明.
研究的目的:
- 调查终身休时间体育活动 (LTPA) 模式与与阿尔茨海默病 (AD) 相关的神经退行性标志物和70岁的认知功能之间的关联.
- 检查LTPA在神经退行性标志物和认知表现之间的关系中的调节作用.
主要方法:
- 来自1946年英国出生队列的468名参与者的前性队列研究,LTPA在36至69岁之间进行了五次评估.
- 参与者被分为LTPA组:从未活跃,仅在50岁之前活跃,仅从50岁起活跃,以及始终活跃.
- 神经成像 (18F-florbetapir PET用于β-粉样蛋白和MRI用于大脑结构) 和认知评估在70岁时进行. 用回归分析来评估直接和缓解效应.
主要成果:
- 持续的LTPA,特别是在50岁前和一生中,与70岁时更大的海马体积直接相关.
- LTPA模式显著改变了认知功能和神经退行性标记物之间的关联,减弱了负面关系.
- 患有早期阿尔茨海默氏症标志物的女性从终身或早期的LTPA中获得了更大的益处,这缓冲了神经退行症的表现.
结论:
- 终身参与LTPA与70岁时更好的认知功能和保存的大脑结构有关,即使存在早期AD标志物.
- 通过保持海马体体积和延迟神经退行症的认知症状,LTPA可能会赋予认知性,在女性中观察到显著的缓冲效应.
- 这些发现突出了体育活动作为疾病修饰干预措施的潜力,为整个生命周期中大脑健康和认知性提供了帮助.
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