CB1受体对手塞洛纳班特 (ANEB-001) 阻断了健康志愿者的急性THC效应:第二阶段随机对照试验
Andriy A Gorbenko1,2, Jules A A C Heuberger1, Maria Juachon1
1Centre for Human Drug Research, Leiden, The Netherlands.
Clinical pharmacology and therapeutics
|February 3, 2025
概括
这项研究表明,塞洛纳班特有效地减少了"高"的感觉,并改善了急性大麻素中毒的个体的警觉. 它还增强了姿势稳定性,支持其用于紧急ACI治疗的发展.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床毒理学 临床毒理学
- 大麻素研究 研究 大麻素研究
背景情况:
- 由于政策变化,因大麻素毒性而访问急诊室的病例在全球范围内正在增加.
- 焦虑和精神病等急性大麻素中毒 (ACI) 症状是由THC的CB1受体激活作用.
- CB1受体对抗剂可能为ACI提供治疗干预.
研究的目的:
- 评估CB1受体对抗剂塞洛纳班特在阻断THC诱导的效果在健康成年人的有效性.
- 评估塞洛纳班特在治疗急性大麻素中毒 (ACI) 的潜力.
主要方法:
- 一项II期,随机,双盲,安慰剂控制的研究,涉及健康成年人.
- 参与者接受了不同剂量的THC与塞洛纳班特或安慰剂联合使用.
- 使用视觉模拟尺度 (VAS) 对"感觉高"和"警觉",以及对姿势稳定性和心率的客观测量来测量THC相关的影响.
主要成果:
- 与安慰剂相比,塞洛纳班特显著降低了"感觉高"的VAS得分,并增加了"警"的VAS得分.
- 随着10毫克和30毫克的塞洛纳班特剂量,观察到身体摇摆的显著减少.
- 没有注意到对心率的显著影响. 恶心和吐在较高剂量时更频繁.
结论:
- 发现10毫克的塞洛纳班特耐受性良好,有效减轻THC诱导的影响.
- 结果支持进一步开发塞洛纳班特作为急性大麻素中毒 (ACI) 的紧急治疗方法.
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