鼻腔皮质类固醇在患有多的慢性鼻炎时的输送方法:系统性审查
Robert E Gurevich1, Ajibola B Bakare2, Dylan A Levy1
1Department of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
非水性鼻内皮质类固醇的输送方法,如雾化剂和喷雾剂,对于带鼻息肉的慢性鼻炎 (CRSwNP) 是安全有效的. 长期坚持是水性喷雾改善症状的关键.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 具有鼻息肉的慢性鼻炎 (CRSwNP) 显著影响生活质量.
- 鼻内皮质类固醇 (INCS) 是CRSwNP的基石治疗.
- 存在各种INCS输送方法,需要对其有效性和安全性进行比较.
研究的目的:
- 系统地审查和比较CRSwNP的不同鼻内皮质类固醇输送方法的疗效和安全性.
- 评估雾化剂,气溶喷雾剂和鼻液对口服皮质类固醇 (OCS) 的有效性.
主要方法:
- 在Embase,CENTRAL,PubMed和Web of Science数据库 (1980-2024) 中进行系统搜索.
- 包括前性随机对照试验 (RCT),比较CRSwNP患者的INCS输送方法.
- 排除了与不适当的比较,干预,群体或给药途径的研究.
主要成果:
- 从最初识别的2282项研究中,包括了5项RCT.
- 非水性输送方法 (雾化器,气溶喷雾剂,鼻滴) 显示效果与OCS相比,安全性提高.
- 长期使用水性喷雾剂改善了症状,但效果不如非水性方法.
结论:
- 非水性INCS输送方法 (雾化器,气溶喷雾剂,鼻滴) 为OCS提供了安全的替代方案,避免了全身副作用.
- 长期坚持水性INCS配方对于实现CRSwNP患者症状改善至关重要.
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