网络毒理学分析揭示了与多种疾病的噪音暴露相关的分子机制
Maria Taboada-Alquerque1, Jesus Olivero-Verbel1
1Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, Colombia.
Toxicology mechanisms and methods
|February 3, 2025
概括
噪音污染作为环境压力因素,影响生物过程,并导致高血压和动脉样硬化等疾病. 患有血管疾病的个体更容易受到长期暴露于噪音的影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物信息学是一种生物信息学.
背景情况:
- 噪音污染是一种环境压力因素,影响了除听力之外的生物过程,主要是通过释放压力激素.
- 了解噪音诱导的生物目标和相关疾病对于公共卫生至关重要.
- 网络毒理学为研究复杂的环境健康问题提供了一种新的方法.
研究的目的:
- 通过网络毒理学方法探索与噪声受管制目标相关的生物过程和疾病.
- 确定与噪音引起的病理相关的关键分子标.
- 评估先前存在血管疾病的个体对噪音污染的脆弱性.
主要方法:
- 在多个数据库中利用网络毒理学和生物信息学分析.
- 确定了577个潜在的分子点,这些点与噪音暴露相关的疾病有关.
- 进行了分子对接研究,以阐明压力激素的作用.
主要成果:
- 确定了577个潜在的噪音调节目标,其中10个来自GEO数据库.
- 噪音污染会影响荷尔蒙反应,细胞因子反应和循环功能,导致高血压,缺血症,动脉样硬化和肝硬化.
- 确定的主要目标包括IL-6,CASP3,AKT1,TNF-α (缺血症),NOS3 (高血压),以及NOS3,TNF-α,AGT,IL-1B (动脉样硬化症).
结论:
- 噪音污染引起的压力激素通过信号通路调节疾病,而不是直接与已识别的枢纽目标结合.
- 血管调节和炎症是将噪音暴露与心血管和脑血管疾病联系起来的关键机制.
- 现有血管疾病的个体对慢性噪音暴露的不良影响的脆弱性增加.
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