在为慢性乙型肝炎治疗的患者中,脂肪性肝病
Jakub Janczura1, Michał Brzdęk2, Krystyna Dobrowolska1
1Collegium Medicum, Jan Kochanowski University, Kielce, Poland
Polish archives of internal medicine
|February 3, 2025
概括
脂肪性肝病 (SLD) 影响了近三分之一的慢性乙型肝炎患者,这些患者使用核胺类类似物. 虽然与并发症相关,但SLD不会影响对治疗的病毒学反应.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒性肝炎病毒性肝炎
- 肝脏疾病 肝脏疾病
背景情况:
- 脂肪性肝病 (SLD) 可以对慢性肝病的预后产生负面影响.
- 了解SLD和慢性乙型肝炎病毒 (HBV) 感染之间的相互作用对于患者管理至关重要.
研究的目的:
- 根据SLD的存在或不存在来评估慢性HBV感染患者的特征.
- 评估SLD对接受核类同类 (NA) 患者的HBV治疗结果的影响.
主要方法:
- 分析了273名患有慢性HBV感染的白人患者队列,这些患者接受了恩特卡维尔或特诺福维尔治疗.
- 患者被评估是否存在SLD,并评估并发病症,肝酶水平和病毒学标志物.
主要成果:
- 近三分之一 (86/273) 的患者患有SLD,男性患病率更高.
- SLD 组表现出更大的伴随性疾病负担,包括肥胖,糖尿病和痛风.
- 尽管SLD组的氨基转移酶活性较高,但HBV DNA病毒载量和对NA治疗的反应在两组之间是可比的.
结论:
- SLD在NA的HBV感染患者中很常见,并与代谢性并发症有关.
- 在慢性乙型肝炎患者中,SLD的存在似乎不会影响对核胺类同类疗法的病毒学反应.
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