相关实验视频
Updated: May 29, 2025

08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
6.9K
肠道微生物组特征与非黑色素瘤皮肤癌患者的免疫检查点抑制剂反应相关:一项探索性研究
Yujie Zhao1, Jacqueline T Ferri2, James R White3
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Microbiology spectrum
|February 3, 2025
概括
肠道细菌的组成可以预测对非黑色素瘤皮肤癌的免疫检查点抑制剂 (ICI) 治疗的反应. 这项研究确定了与治疗结果相关的特定细菌属和代谢途径,表明了ICI疗效的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 疗法为某些皮肤癌提供了革命性的结果.
- 很大一部分患者没有从ICI治疗中受益.
- 关于肠道微生物群在非黑色素瘤皮肤癌 (NMSCs) 的ICI治疗中的作用的数据有限.
研究的目的:
- 调查肠道微生物群结构和功能与NMSC患者ICI治疗结果之间的关联.
- 确定潜在的微生物生物标志物,预测NMSC中的ICI反应.
主要方法:
- 从患有基底细胞癌,默克尔细胞癌和皮肤状细胞癌 (CSCC) 患者的68个便样本进行了16S rRNA基因扩增序列测序.
- 纵向采样和细菌组成的瘤依赖差异分析.
- 非向的便代谢学来识别相关的微生物代谢物和途径.
主要成果:
- 在所有瘤类型中,在响应者 (R) 和非响应者 (NR) 之间确定了10种不同的细菌系.
- 在CSCC患者中,10个属和20个物种将R与NR区分开来,具有明显的丰富途径.
- 未定位的代谢学揭示了九个KEGG途径与CSCC中的ICI疗效相关.
结论:
- 这项探索性研究表明,肠道微生物群的特征与NMSC中的ICI疗效有关.
- 研究结果强调需要进行更大规模的研究来验证潜在的预测或预后生物标志物.
- 微生物群修饰可能为接受ICI的NMSC患者提供补充治疗策略.
更多相关视频
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.4K
07:42Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
Published on: February 7, 2021
4.8K
相关概念视频
Tumor Immunotherapy
464
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
464
Cytotoxic T Cells-mediated Immune Response
833
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
833