在埃斯瓦提尼的医院出生监测中的出生缺陷和不良妊娠结果
Michelle M Gill1, Philisiwe Ntombenhle Khumalo1, Heather J Hoffman2
1From the Elizabeth Glaser Pediatric AIDS Foundation, Washington, District of Colombia and Mbabane, Eswatini.
The Pediatric infectious disease journal
|February 3, 2025
概括
这项研究发现,在接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染母亲所产生的婴儿中,神经管缺陷 (NTD) 的风险没有增加. 然而,与没有艾滋病毒的妇女相比,艾滋病毒感染的妇女的死产和早产率较高.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 之前的一项研究表明,在怀孕时使用基于多卢特格拉维尔的抗逆转录病毒疗法 (ART) 可能存在神经管缺陷 (NTD) 风险.
- 在埃斯瓦提尼的监测评估了与母亲的艾滋病毒状况和ART相关的出生缺陷和妊娠结果.
研究的目的:
- 评估埃斯瓦提尼出生缺陷和不良妊娠结果的流行情况.
- 为了比较艾滋病毒感染和没有艾滋病毒感染的妇女之间的结果,以及按ART治疗方案和时间.
主要方法:
- 对临床记录进行回顾,对妊娠史和HIV/ART状态进行回顾.
- 对有出生缺陷的婴儿进行采访和摄影记录.
- 医学遗传学家对数据和图像进行盲目审查.
主要成果:
- 在艾滋病毒感染和没有艾滋病毒感染的母亲之间,重大出生缺陷或NTD没有显著差异.
- 在怀孕时,在接受多卢特格拉维尔治疗的母亲与其他ART治疗时,在重大缺陷或NTD中没有显著差异.
- 在艾滋病毒感染的母亲中观察到较高的死产,低出生体重和早产率.
结论:
- 来自埃斯瓦提尼的数据支持怀孕妇女中含有多卢特格拉维尔的ART缺乏NTD安全信号.
- 与没有艾滋病毒的妇女相比,尽管有ART,但艾滋病毒感染的妇女仍然存在高的不良分娩结果.
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