临床分析和风险因素与非结核性真菌细菌感染的预后不佳有关
Jinjing Chai1, Sujie Zhang2, Chong Ma2
1Emergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Virulence
|February 3, 2025
概括
非结核性真菌菌病 (NTM) 正在上升. 高查尔森并发症指数,中性粒细胞与淋巴细胞比率 (NLR) 和传播感染预测NTM患者的治疗结果不佳. NLR和NMLR有效地预测死亡率.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 微生物学 微生物学
背景情况:
- 在全球范围内,非结核性菌根 (NTM) 疾病的发病率和流行率不断上升.
- 需要确定非HIVNTM患者的预后和死亡风险因素.
- 肺部疾病和扩散性感染在临床上面临着重大挑战.
研究的目的:
- 为了确定NTM疾病的非艾滋病毒患者的预后和死亡率的风险因素.
- 评估特定生物标志物对NTM患者结果的预测价值.
主要方法:
- 北京联合医学院医院电子医疗记录 (2013-2022) 的回顾性审查.
- 包括147名被诊断患有NTM感染的患者.
- 对临床,实验室,微生物学,治疗和结果数据的统计分析.
主要成果:
- 菌复合体和菌是最常见的NTM物种.
- 在NTM肺部疾病中,与Aspergillus和Pseudomonas aeruginosa的同时感染率较高.
- 不良结果的独立预测因素包括高的查尔森并发症指数 (CCI),高的中性粒细胞与淋巴细胞比率 (NLR),血液病和传播感染.
- 对于NLR (0.751) 和中性粒细胞与单细胞加淋巴细胞比率 (NMLR) (0.763) 的AUC值表明死亡率的预测值.
结论:
- 高CCI,NLR,血液病和传播感染是NTM患者死亡的重要风险因素.
- NLR和NMLR作为预测NTM疾病死亡率的有价值的生物标志物.
- 了解这些风险因素可以指导临床管理并改善患者的治疗结果.
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