根据小儿科囊性纤维化相关的肺部恶化病史的微生物学史,初步选择抗生素
Jillian Grapsy1, Ching-Sui Ueng1, Karisma Patel1
1Department of Pharmacy, Children's Medical Center Dallas, Dallas, Texas, USA.
Pediatric pulmonology
|February 3, 2025
概括
儿童囊性纤维化 (CF) 患者
科学领域:
- 儿科肺病学 儿科肺病学
- 传染病 传染病 传染病
- 微生物学 微生物学
背景情况:
- 囊性纤维化 (CF) 基金会的指导方针缺乏关于肺部恶化 (PEx) 经验性抗生素选择的具体细节.
- 了解CF相关PEx抗生素选择的当前做法对于优化治疗至关重要.
- 这项研究通过检查基于患者病史的抗生素选择来解决这一差距.
研究的目的:
- 描述患者特异性微生物病史在儿科患者CF相关PEx的初始抗生素选择中的利用.
- 确定在住院期间对实证抗生素疗法进行变化的原因.
主要方法:
- 对患有CF相关的PEx.Ex.住院的儿科患者 (1-21岁) 的回顾性单中心研究.
- 2016年8月至2018年7月期间从达拉斯儿童医疗中心收集的数据.
- 分析了156例符合纳入标准的患者体验.
主要成果:
- 金黄色葡萄球菌, Pseudomonas aeruginosa 和 Stenotrophomonas maltophilia 是常见的目标生物.
- 自最后一次生长以来的中位时间在向生物和非向生物之间有所不同,有显著的重叠.
- 最初的抗生素疗法在78.2%的病例中表现出对接收培养分离物的敏感性.
结论:
- 患者特定的微生物病史,包括自最后一个生物体生长以来的时间,会影响CF PEx的初始抗生素选择.
- 延长历史生物体监测超过一年并没有改善CF患者入院隔离物的覆盖范围.
- 目前的做法显示出变化,但在经验性抗生素选择中考虑历史微生物学数据.
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