肠道微生物群的饮食指数与美国成年人中中风有关
Jingjing Liu1, Shaoqiang Huang1
1Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China. drhuangsq@fudan.edu.cn.
Food & function
|February 3, 2025
概括
较高的肠道微生物群 (DI-GM) 饮食指数得分,反映出更好的肠道健康,与中风的发病率较低有关. 这种关联在30岁及以上的成年人中尤为显著.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 饮食-微生物群-肠道-大脑轴在维持大脑健康方面发挥着至关重要的作用.
- 肠道微生物群的饮食指数 (DI-GM) 量化了与肠道微生物群多样性相关的饮食质量,其中较高的分数表明肠道更健康.
- 在DI-GM和中风风险之间的关系仍然在很大程度上未被探索.
研究的目的:
- 调查肠道微生物群的饮食指数 (DI-GM) 与中风患病率之间的关联.
- 为了探索不同年龄组之间的这种关联.
主要方法:
- 从20岁及以上的全国健康和营养检查调查 (NHANES) 中对48,677名参与者的横截面分析.
- 使用多变量加权后勤回归来评估DI-GM和中风之间的关联,并根据相关的共变量进行调整.
- 进行了受限立方线 (RCS) 和子组分析,以进一步阐明这种关系.
主要成果:
- 在多变量调整后,较高的DI-GM得分与较低的中风患病率显著相关 (OR:0.93;95%CI:0.89-0.98;P=0.003).
- 这种反向关联在30岁及以上的成年人中更为明显.
- 在较年轻的年龄组 (20-29岁) 中没有观察到显著的关联.
结论:
- DI-GM显示了与中风患病率的反向和线性关联.
- 促进支持肠道微生物群多样性的饮食可能是预防中风的策略,特别是在老年人中.
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