高血糖蛋白血症在动脉样硬化中的作用:从长椅到床边
Wende Tian1,2, Jianqing Ju1, Baoyi Guan3
1National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing China.
Annals of medicine
|February 3, 2025
概括
高水平的homocysteine (HHcy) 通过炎症和氧化应激加速动脉样硬化. 本综述将HHcy机制与预防和管理策略联系起来,以预防和管理这种主要的死亡原因.
科学领域:
- 心血管科学 心血管科学
- 代谢性疾病研究研究
- 血管生物学 血管生物学
背景情况:
- 动脉样硬化是全球主要的死亡率驱动因素.
- 超同胞蛋白血症 (HHcy) 是一个显著的,可修改的危险因素.
- HHcy有助于内皮功能障碍,氧化应激和血管炎症.
研究的目的:
- 在动脉样硬化中审查HHcy的机制.
- 将机械学的见解与临床应用联系起来.
- 讨论HHcy诱导动脉样硬化的预防和管理策略.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对有关HHcy和动脉样硬化的出版物的分析.
- 检查HHcy在动脉动脉生成中的作用.
主要成果:
- HHcy通过炎症,氧化应激和表观遗传修饰加速动脉样硬化.
- 涉及到脂蛋白代谢的变化.
- HHcy 是一个有助于风险因素和动脉动脉过程的加速器.
结论:
- 在动脉样硬化的进展中,HHcy起着复杂的作用.
- 本综述巩固了最近的进展,将基础研究与临床实践联系起来.
- 了解HHcy机制对于治疗动脉样硬化至关重要.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
43
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
43
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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