预防性阿司匹林剂量和产前
Ellen Kupka1,2, Susanne Hesselman2,3, Jóhanna Gunnarsdóttir3,4,5
1Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
JAMA network open
|February 3, 2025
概括
这项研究发现,在服用150-160毫克或75毫克阿司匹林的孕妇之间,孕前症发生率或出血并发症没有差异. 这两种阿司匹林剂量在预防产前方面似乎同样有效.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 孕前是孕产妇和胎儿发病的一个重要原因.
- 低剂量阿司匹林通常用于妊娠前的预防,但最佳剂量仍在争论中.
- 有时使用较高的阿司匹林剂量 (150-160毫克),但与较低剂量 (75毫克) 相比,其疗效和安全性尚未得到充分证实.
研究的目的:
- 为了比较接受150-160毫克阿司匹林与75毫克阿司匹林的孕妇之间产前和产后出血的发生率.
- 评估不同低剂量阿司匹林治疗方案的安全性和有效性,以预防产前.
主要方法:
- 在瑞典进行的一项全国性队列研究包括13,828名从2017年至2020年接受低剂量阿司匹林 (75-160毫克) 的妇女.
- 孕前的诊断和产后出血是主要的结局.
- 用双倍强大的反向概率加权回归调整来估计相对风险.
主要成果:
- 在150-160毫克阿司匹林组 (9.5%) 和75毫克组 (8.9%) 之间没有观察到孕前发病率的显著差异.
- 产后出血率在两组之间也相似 (6.9%对6.4%).
- 对产前和产后出血的调整后的相对风险显示,两个阿司匹林剂量之间没有显著差异.
结论:
- 这项研究表明,150-160毫克和75毫克的阿司匹林剂量在预防产前方面是相似的,并且在引起产后出血方面没有显著差异.
- 任何剂量都可能是怀孕期间阿司匹林预防的合理选择.
- 进一步的大规模随机对照试验是有必要的,最终确定最佳的阿司匹林剂量,以预防产前.
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