通过Web应用程序提供认知行为疗法的有效性,用于低值抑郁症,低值失眠和低值恐慌:开放标签6臂随机临床试验试点研究
Kayoko Taguchi1, Mirai Miyoshi2, Yoichi Seki1
1Research Center for Child Mental Development, Chiba University, Chiba, Japan.
JMIR formative research
|February 3, 2025
概括
通过互联网提供的认知行为疗法 (ICBT) 有效地改善了下值抑郁症 (SD) 和下值失眠 (SI). 虽然有望预防症状进展,但由于结果不确定的原因,下值恐慌 (SP) 需要进一步调查.
科学领域:
- 心理健康 心理健康
- 数字治疗学数字治疗学
- 精神病学是一个精神病学.
背景情况:
- 低于值的症状虽然不符合诊断标准,但会引起严重的痛苦和功能障碍.
- 对低于值症状的干预措施有效地防止过渡到完全的精神疾病.
- 对于低于值症状的具体干预报告仍然不足.
研究的目的:
- 评估通过互联网提供的认知行为疗法 (ICBT) 对下值抑郁症 (SD),下值失眠 (SI) 和下值恐慌 (SP) 的有效性.
- 探索每个子值组的有效性结果的最小重要变化 (MIC).
主要方法:
- 参与者 (18-70岁) 被分为SD,SI或SP组,并随机分配到ICBT或虚假应用控制.
- 从基线到4周的随访期间,使用CESD (SD),PSQI (SI) 和PAS (SP) 评估了主要结果.
- 二次结果包括GAD-7,PHQ-9和其他初级结果措施;使用完整病例分析和重复措施ANOVA.
主要成果:
- ICBT显著改善了SD组的CESD分数 (P<.001) 和SI组的PSQI分数 (P=.01).
- 在SP组的PAS得分中没有发现显著差异 (P=.94).
- 该研究包括846名SD组的参与者,1106名SI组的参与者,597名SP组的参与者.
结论:
- 在ICBT程序"Mentre"有效地改善SI和SD,表明潜在的预防进展到完全值障碍.
- 非指导性ICBT显示出对管理下值抑郁症和失眠的有希望.
- 需要进一步的研究来定义下值恐慌,并调查症状特异性干预措施.
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