双边性和呼吸道上皮腺腺形瘤的2型炎症之间的联系:一项两中心的回顾性队列研究
Yujin Heo1, Sang Duk Hong1, Hyo Yeol Kim1
1Department of Otorhinolaryngology, Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
双侧鼻腔呼吸道上皮腺腺形瘤 (REAH) 显示2型炎症增加,与喘和之前的手术有关. 这表明与单边的REAH相比,具有不同的病原性,强调了评估中双边性的重要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 鼻呼吸道上皮腺腺瘤 (REAH) 是一种罕见的,良性鼻病变,其病因不明.
- 现有的假设表明REAH的炎症或瘤起源.
- 目前缺乏REAH的正式亚型分类,尽管临床异质.
研究的目的:
- 为了分析经过手术治疗的鼻腔REAH的临床特征.
- 根据REAH双边性来调查疾病特征.
- 探索REAH双边性和2型慢性鼻炎之间的关系.
主要方法:
- 对21名病理确诊REAH.患者的回顾性分析.
- 包括2008年11月至2023年11月期间的内镜鼻手术患者.
- 人口统计数据,喘病史,先前的鼻外科手术,血清中氨基酸蛋白水平和JESREC得分都被分析了关于REAH双边性的数据.
主要成果:
- 11个病例 (52.4%) 是双边的 (REAH_bi),10个 (47.6%) 是单边的 (REAH_uni).
- REAH_bi与喘,先前的鼻手术和炎症多重症有显著的相关性.
- 在REAH_bi病例中,血清氨基酸和JESREC评分升高;没有发现复发.
结论:
- 双边产生的REAH表现出明显的2型炎症特征.
- 研究结果表明,双边和单边REAH之间的病原发生可能存在差异.
- 强调对临床评估和进一步研究REAH病理生理学的双边性评估的重要性.
更多相关视频
07:00Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
08:44Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
相关概念视频
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
