在辅助生殖技术中发生胎盘前风险:一个北欧人口研究与兄弟姐妹分析
Eirik Landsverk1, Kjersti Westvik-Johari1,2, Ulla-Britt Wennerholm3
1Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway.
PLoS medicine
|February 3, 2025
概括
辅助生殖技术 (ART) 增加了胎盘前风险,特别是新鲜的胚胎细胞移植. 与自然受孕相比,接受ART的子宫内膜异位症妇女面临的风险最高,这凸显了针对性预防策略的必要性.
科学领域:
- 生殖医学 生殖医学
- 产科 产科 产科 产科 产科
- 周围生理学 周围生理学
背景情况:
- 辅助生殖技术 (ART) 与胎盘前产的风险更高有关.
- 机制可能涉及胚胎培养时间,冷保存和不孕症原因.
- 母体内分析有助于将ART的影响与稳定的母体因素隔离.
研究的目的:
- 在ART后调查胎盘前风险.
- 检查胚胎培养时间,冷保存和不孕因素的影响.
- 使用母体内分析来考虑稳定的母体因素.
主要方法:
- 来自北欧国家 (1988-2015年) 的全国性注册数据.
- 多级逻辑回归比较ART与自然受孕.
- 在母体内进行分析,以控制稳定的母体特征.
主要成果:
- 与自然受孕相比,ART怀孕的胎盘前风险更高 (或4.16在人群中,或2.64在母亲内).
- 新鲜胚胎移植显示出比冷胚胎移植更大的风险增加.
- 新鲜的胚胎细胞移动带来了最高的风险;冷的裂变阶段移动是最低的.
- 患有子宫内膜异位症的女性在ART后具有最高的人口水平风险 (OR 9.35).
结论:
- 在ART后的胎盘前风险因胚胎培养,冷保存和不孕症类型而异.
- 新鲜胚胎转移,特别是胚胎囊,与最高风险有关.
- 通过ART怀孕的子宫内膜异位症患者的风险增加,需要进一步调查预防.
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