突变性菌杆菌 (Streptococcus mutans) 调节了Candida albicans在细菌-真菌相互作用中的无处不在的修饰
Yixin Zhang1,2, Zhen Gu1,2, Zhengyi Li1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Chengdu, China.
PLoS pathogens
|February 3, 2025
概括
Streptococcus mutans 细胞外膜囊泡 (EMVs) 通过改变蛋白质无处不在性来促进 Candida albicans 的生长和毒性. 这种相互作用通过培养 cariogenic 口腔生物膜来驱动牙虫的病原性.
科学领域:
- 微生物学 微生物学
- 口腔生物学 口腔生物学
- 生物化学 生化学
背景情况:
- 牙病变的发病过程涉及斑块生物膜中Streptococcus mutans和Candida albicans之间的相互作用.
- 了解微生物相互作用对于开发有针对性的空预防策略至关重要.
研究的目的:
- 研究S. mutans如何通过细胞外膜囊泡 (EMV) 调节C. albicans的生长和毒性.
- 为了探索在S. mutans-C. albicans相互作用中无处不在调节的作用.
主要方法:
- 采用了一个跨井共同培养模型,用于S. mutans和C. albicans之间的接触独立相互作用.
- 分析了S. mutans与C. albicans的EMV关联.
- 在共同培养过程中对C. albicans进行了定量无处不在的分析.
主要成果:
- S. mutans EMVs促进了C. albicans生物膜的形成和生长.
- S. mutans显著改变了C. albicans的无处不在格局,影响了10,661个地点.
- 由S. mutans调节的C. albicans超氧化物脱酶-3的无处不在导致其降解,增加了活性氧物种,并刺激了生长.
结论:
- 电磁流体和无处不在调节是S. mutans-C. albicans相互作用中的关键机制.
- 这些机制有助于 cariogenic 口腔生物膜和牙的发展.
- 这项研究为牙斑 dysbiosis 的分子基础提供了新的见解.
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