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Updated: May 6, 2026

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基因预测IL-18抑制和心血管事件的风险:孟德尔随机化研究

Stephen O Brennan1,2, Peter J Kelly1,3,4, Sarah Gorey3

  • 1Departments of Neurology (S.O.B., P.J.K.), Mater Misericordiae University Hospital, Dublin, Ireland.

Circulation
|February 3, 2025
PubMed
概括

No abstract available in PubMed .

关键词:
心血管疾病遗传学抗胰岛素

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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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