抗精神病药物的影响与饮食相关的结果:混合方法系统审查
Rasha Alkholy1,2,3, Karina Lovell1,2,3, Penny Bee1,2,3
1Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
PloS one
|February 3, 2025
概括
抗精神病药物可以通过影响饮食习惯导致体重增加. 目前的研究缺乏足够的高质量研究来证实这些影响,强调需要对这一关键副作用进行更严格的研究.
科学领域:
- 心理药理学 心理药理学
- 临床心理学 临床心理学
- 证据综合 证据综合
背景情况:
- 体重增加是几乎所有抗精神病药物的显著不良影响.
- 由于其临床严重性,了解抗精神病药物诱导的体重增加背后的机制至关重要.
- 抗精神病药对与饮食相关的结果的影响是导致体重增加的潜在机制.
研究的目的:
- 综合对第一代和第二代抗精神病药物对饮食相关结果的影响的定量研究.
- 综合定性研究,探讨患者与抗精神病药物有关食欲和饮食行为的经验.
- 用GRADE和GRADE-CERQual框架评估这些影响的证据确定性.
主要方法:
- 通过Medline,PsycInfo和Web of Science进行系统的文献搜索.
- 使用投票计数合成的定量数据;使用专题合成合成的定性数据.
- 使用GRADE和GRADE-CERQual框架评估证据确定性.
主要成果:
- 从8,746个引用中确定了61项研究 (55项定量,6项定性).
- 对定量和定性发现的证据确定性从低到非常低不等.
- 定性数据表明,食物环境是影响抗精神病药和饮食行为关系的重要因素.
结论:
- 包含的定量研究的严重局限性和缺乏定性证据影响了审查的有效性.
- 从经过良好的研究中获得的证据不足以确定抗精神病药物对与饮食相关的结果的影响.
- 需要进一步的高质量,安慰剂对照试验来澄清这些影响.
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