饮食酸负荷和人类健康:观察性研究的系统审查和元分析
Maryam Abbastabar1, Zahra Mohammadi-Pirouz2, Shabnam Omidvar3
1Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Nutrition reviews
|February 3, 2025
概括
饮食中的高酸负荷 (DAL) 与2型糖尿病和癌症的风险增加有关. 这次元分析综合了关于DAL,潜在酸负载 (PRAL) 和健康结果的内源性酸净产量 (NEAP) 的证据.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 饮食中的酸负荷 (DAL) 显著影响人类健康.
- DAL是通过潜在的酸负荷 (PRAL) 和净内源性酸产量 (NEAP) 来量化.
研究的目的:
- 系统地综合关于DAL (PRAL和NEAP) 与各种健康结果之间的关联的观察证据.
- 评估这些协会的证据可信度.
主要方法:
- 在Medline,EMBASE,Scopus和Web of Science进行了系统的文献搜索.
- 包括118项观察性研究 (n=1,014,081),分析了38个健康结果.
- 证据的可信性是使用预先定义的标准进行分级的,包括效果大小,异质性和偏见评估.
主要成果:
- 有令人信服的证据 (I类) 将更高的PRAL和NEAP与2型糖尿病 (T2D) 联系起来.
- 有令人信服的证据 (I类) 将更高的NEAP与整体癌症联系起来,有高度暗示的证据 (II类) 将PRAL与整体癌症联系起来.
- 强烈暗示性证据 (II类) 将PRAL与缩血压和NEAP与乳腺癌联系起来.
结论:
- 饮食中较高的酸含量与T2D和整体癌症的风险增加有关.
- 由于包含的研究的观察性质和一些证据较弱,建议谨慎使用.
- 建议进行进一步的队列研究,以解决潜在的偏见并确认关联.
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