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Updated: May 29, 2025

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多功能和受控合成可降解,水溶性玻璃刷聚合物与聚二硫化) 脊椎由α-酸衍生

Ivan O Levkovsky¹, Lucca Trachsel¹, Hironobu Murata¹

¹Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.

ACS macro letters

|February 3, 2025

概括

研究人员开发了具有二硫化物骨干的可降解瓶刷 (BB) 聚合物,用于先进的药物输送. 这项创新提高了BB聚合物的功能,生物相容性和生物医学应用的可持续性.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

瓶刷 (BB) 聚合物为药物输送提供了优势,包括高功能群密度和改善生物分布.
然而,它们的不可降解的骨干限制了需要受控清除和生物降解性的应用.

研究的目的:

开发可降解的BB聚合物,具有可调整的架构和可预测的分子重量,用于增强药物输送应用.
通过引入可切割的二硫化物键来解决不可降解的BB聚合物骨干的局限性.

主要方法:

通过可逆添加碎片链转移 (RAFT) 合成可降解BB聚合物,对α-酸 (LA) 和烯酸盐基聚合物进行共聚.
利用原子转移激素聚合 (ATRP) 接种方法来制造具有受控分子量和低分散度的BB聚合物.
在温和的还原条件下,由于可裂解的二硫化物键,证明了骨干降解.

主要成果:

达到高摩尔质量 (650-2700 kg/mol) 和高脊柱聚合度,分散度低 (1.30-1.53).
成功合成了带有各种侧链的BB聚合物 (水友性,阴离子,阳离子,离子),展示了广泛的单体相容性.
在温和的降解条件下证实了脊柱退化,使得可控清除.

结论:

开发了一种可扩展的方法,用于生产具有可调节性质的水溶性,可降解的BB聚合物.
这项工作通过引入生物降解性,增强功能性,生物相容性和可持续性来推进BB聚合物的药物输送潜力.

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