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麦克罗戈尔的使用以加速极度早产婴儿的食进步

Kirstin Barbara Faust^1,2,3, Mariia Lupatsii⁴, Frederike Römer¹

¹Department of Pediatrics, University Hospital of Lübeck, Lübeck, Germany.

|February 3, 2025

概括

在极度早产的婴儿中,早期使用麦克罗戈尔显著加快了食进步,并支持肠道微生物组的发展. 这种干预措施有望改善脆弱新生儿的治疗结果.

科学领域:

新生儿科学新生儿科学
儿科胃肠病学儿科胃肠病学
微生物组研究微生物组研究

背景情况:

推迟肠道营养会增加极度早产婴儿的不良结果.
关于促进美疏散和胃肠道运动的疗法,证据有限.
麦克罗戈尔对早产婴儿的食耐受性和微生物群的影响需要进行研究.

研究的目的:

为了确定早期马克罗戈尔给药对早产婴儿 (<27周妊娠期) 食耐受性的影响.
评估宏醇对肠道微生物群在这个脆弱人群中的影响.

主要方法:

进行了两个观察性队列研究:德国新生儿网络 (GNN) 和新生儿免疫调节 (IRoN) 研究.
在GNN中,NICU与高或低早期巨醇使用量进行了比较.
IRoN评估了微生物组在实施宏醇之前和之后的变化.

主要成果:

在使用宏醇 (GNN: 14 vs. 16天;IRoN: 12 vs. 16天) 的NICU中观察到更快的进步到全肠养.
与使用macrogol无关的败血症或腹部并发症的风险增加.
较高的Bifidobacterium longum丰度与更快的养进步相关.

结论:

早期,非标签的麦克罗戈尔使用可能会促进高度脆弱的早产婴儿的食进步.
这些发现支持需要进行随机对照试验,以确认macrogol的疗效.
麦克罗戈尔可以积极影响肠道微生物组合,帮助营养支持.

关键词:

极度早产的婴儿是非常早产的进食的进步是因为进食的进步.麦克罗戈尔是一个巨大的谷歌.营养营养营养营养营养

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