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Updated: Apr 28, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
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在SCA3中大脑脂质失调:在患者和小鼠中进行的一项比较研究

Alexandra F Putka1, Varshasnata Mohanty2, Stephanie M Cologna3

  • 1Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

Neurobiology of disease
|February 3, 2025
PubMed
概括

3型脊髓小脑动症 (SCA3) 涉及广泛的大脑脂质减少,特别是髓脂质,这表明它在白质缩中起着关键作用,并为这种致命的神经退行性疾病提供了潜在的治疗点.

关键词:
胆固醇 胆固醇 胆固醇利皮多米克 (Lipidomics) 是一种消化剂.分子机制的分子机制神经退行性疾病是一种神经退行性疾病.基体细胞的基体细胞硫酸盐化物 硫酸盐化物

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