Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

601
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
601
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

461
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
461
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

3.6K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
3.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

3.9K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
3.9K
Structure and Function of Platelets01:18

Structure and Function of Platelets

963
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
963
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.5K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Medicinal Plant-Derived Exosome-like Nanoparticles: From Basic Research to Biomedical Applications.

Pharmaceutics·2026
Same author

Genetic Interruption of PD-1/PD-L1 as an Alternative Means for Immune Checkpoint Blockade in Cancer: A Review.

Pharmaceutics·2026
Same author

LIBRE GO!: A Mobile Application for Longitudinal Social Participation Assessment and Resources Connection after Burn Injury.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Transportation mode impact on care service utilization and community integration after burn injury - A Burn Model System National Database Study.

Burns : journal of the International Society for Burn Injuries·2026
Same author

The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion.

PloS one·2026
Same author

Treatment With 9-mg Mazdutide for Weight Reduction in Chinese Adults With Obesity: The GLORY-2 Randomized Clinical Trial.

JAMA·2026

相关实验视频

Updated: May 29, 2025

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

21.5K

特里普坦林通过减少Gp1bα表达来损害血小板功能和血栓形成.

Hanchen Gao1, Jian Huang1, Xin Huang1

  • 1Department of Hematology, Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang Province, China.

European journal of pharmacology
|February 3, 2025
PubMed
概括

来自传统中医药的一种化合物丁在小鼠和人类研究中被发现可以抑制血小板功能和血栓形成. 这一发现表明,对于管理血栓事件的潜在治疗应用.

关键词:
在 Gp1bα 中.血液静止 血液静止 血液静止血小板是血小板的组成部分.血栓形成的原因是血栓形成.三甲林是一种三甲林.

更多相关视频

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

11.9K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

141

相关实验视频

Last Updated: May 29, 2025

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

21.5K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

11.9K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

141

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 血液静止 血液静止 血液静止
  • 传统中国医药 传统中国医药

背景情况:

  • 三氨酸 (Couroupitine A) 是由含的中国传统草药衍生而成的.
  • 它表现出各种药理活动,但其对血小板功能和血栓形成的影响尚不清楚.
  • 了解丁对凝血的影响对于其治疗潜力至关重要.

研究的目的:

  • 为了研究平素对血小板功能的影响.
  • 为了评估平林对体外和体内血栓形成的影响.
  • 阐明三甲林对血小板的影响背后的分子机制.

主要方法:

  • 血小板功能测试是在小鼠和人类血小板上进行的.
  • 使用了体外和体内血栓形成模型,包括微流体和FeCl3诱导的血栓形成.
  • 进行了蛋白质组学分析,以确定三氨酸的分子标.

主要成果:

  • 在小鼠中,三显著抑制了血小板功能和血栓形成.
  • 人类血小板聚合,扩散和凝块收缩被三抑制.
  • 三甲林治疗导致Gp1bα的表达减少,并抑制了参与血小板激活和凝固的关键信号通路.

结论:

  • 特里普坦林显示出强大的抗血小板和抗血栓作用.
  • 该化合物干扰了血小板激活,聚合和凝血级联.
  • 特里普坦林对Gp1bα表达的抑制是其作用的关键机制.