与人类Mpox感染相关的风险因素:系统性审查和元分析
Chigozie Louisa Jane Ugwu1, Nicola Luigi Bragazzi1,2, Jianhong Wu1
1Laboratory for Industrial & Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.
BMJ global health
|February 3, 2025
概括
麻疹风险因素包括与动物接触,艾滋病毒,性传播感染,未受保护的性行为和与感染者密切接触. 小天花疫苗接种显著降低了Mpox感染的风险,有助于公共卫生战略.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 在2022-2023年爆发期间,Mpox (以前的麻疹) 成为全球健康问题.
- 这项研究综合了全球人类Mpox传播风险因素的证据.
研究的目的:
- 确定和综合人类Mpox传播的关键风险因素.
- 为公共卫生规划和有针对性的干预提供信息.
主要方法:
- 在Scopus,Embase,Web of Science和PubMed的系统文献搜索到2024年3月.
- 根据PRISMA指导方针对31项选定的研究进行元分析.
- 使用纽卡斯尔-太华规模评估的偏差风险.
主要成果:
- 确定了重要的Mpox风险因素:与动物接触 (OR=5.61),艾滋病毒 (OR=4.46),性传播感染 (OR=1.76),未受保护的性行为 (OR=1.53),与感染者的接触 (OR=2.39),与男性发生性关系的男性 (OR=2.18),以及多个伴侣 (OR=1.61).
- 接种天花疫苗显示具有保护作用 (OR=0.24).
结论:
- 了解这些风险因素对于有效的Mpox控制至关重要.
- 研究结果支持针对高风险人群的有针对性的公共卫生干预措施.
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