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Updated: May 29, 2025

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
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Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses

Published on: February 25, 2011

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对BMV TLS氨基化动态的结构洞察

Wen Yang1, Ran Yi1,2, Jing Yao3,4

  • 1Department of Clinical Laboratory, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Nature communications
|February 3, 2025
PubMed
概括

木马赛克病毒使用类似tRNA的结构来模仿宿主功能进行复制. 这项研究揭示了病毒结构和宿主酶之间的动态相互作用,这对病毒复制至关重要,并提供抗病毒标.

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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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